Is poor glycemic control associated with free testosterone level in Iranian diabetic men?
Diabetes mellitus is a common metabolic disease. Its association with testosterone has already been shown in many studies. Considering the role of testosterone hormone in impotency, fatigue, osteoporosis and fracture this study aimed to investigate the free testosterone in type 2 diabetes and its association with glycemic control index.
Materials and Methods
In this cross-sectional study, 50 male diabetic patients over 20 years based base on inclusion criteria registered. Malignancy, history of head trauma, surgery or radiation, dysfunction of kidney, thyroid or pituitary and any previous chronic disease and drugs that may interfere with testosterone levels, excluded for all subjects, blood samples were taken to measure serum free testosterone levels, fasting blood glucose, and hemoglobin A1C. Demographic information was also completed by the patient
The mean ± standard deviation of patients' age was 57.5 ± 10.6 years. 22% of patients had BMI> 30 kg/m² and 54% had abdominal obesity. Only 14% of patients had good glycemic control index (HBA1c< 7%) There was not a significant correlation between free testosterone level with BMI (P=0.963, r=0.007), waist circumference (P=0.152 and r=0.206), and HbA1c levels (P=0.223 and r=0.172).
In general, although the results of this study showed that free testosterone level was not statistically significant correlation with glycemic index in type2 diabetic patients, but, more studies are recommended considering the wider statistical sample size for better conclusions.
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