The combined effect of resveratrol supplement and Endurance training on IL-10 and TNF- α in type 2 diabetic rats

The use of supplements, herbal extracts, and exercise training for the treatment of type 2 diabetic has become widespread nowadays. The purpose of this study was to evaluate the effect of endurance training and resveratrol consumption on IL-10 and TNF- α in type 2 diabetic rats. During this experiment 32 diabetic rats with high-calorie diet Sprague Dowley race with an average weight of 250 ±10 gram, were randomly divided into four groups, including the “control group”, the “supplement group”, the “training group” and the “training + supplement group”. For up to 8 weeks, the “training” and the “training + supplement” groups participated in 3 endurance training sessions weekly; each session included 30 minutes of endurance training with an intensity of 70 to 75% VO2max.  Moreover, the “supplement” and the “training + supplement” groups were given 10 milligram daily doses of resveratrol consumption solution per kilogram of body weight. The outcome data was analyzed using one-way analysis of variance (ANOVA) with significance level of (p≤0.05). The results have shown that eight weeks of training and resveratrol consumption had no significant effect on the serum level of IL-10. but the level of TNF-α, Fasting Glucose, Insulin and insulin resistance decreased significantly in the groups (p= 0.001). Based on the findings of this study, the combination of resveratrol supplementation and endurance training can reduce the inflammatory factors of type II diabetes.