Synergistic Effect Of Treadmill Exercise And Green Tea Extract On Cutaneous wound Healing In Diabetic Mice

In the study , synergistic effect of green tea (camellia sinesis) extract and treadmill aerobic exercise on wound healing in streptozotocin induced diabetic mice has been investigated.  

The number of 50 male mice with the approximately weight of 30-35 gram health and adult are put in 5 groups: non diabetic – immobile , diabetic - immobile, diabetic exercise - diabetic and  immobile with green tea extract , diabetic with synergism of exercise and green tea extract. After inducing of diabetes using sterptozotocin mice were killed and in days 3-7-14-21 macroscopic and histopathologic analysis were performed.  

The results indicated that in synergistic group of  green tea extract and treadmill exercise , wound area decreased and fibroblast  increased after 7 days significantly compared with other groups (p<0.001).PMN cells decreased after 3 days significantly compared with other groups (p<0.001).  

The results suggest that green tea extract and treadmill exercise have synergistic effect on wound healing in diabetic mice.