Evaluation the toxicity of Titanium dioxide nanoparticles on hematological and biochemical parameters in mice

Considering the development of nanotechnology and extensive use of nanoparticles in different fields of industry, there are concerns about their toxic effects on the environment and human health. The objective of this study was to evaluate the toxicity of titanium dioxide nanoparticles (TiO2-NP) on the hematological and serum parameters of mice. In the present study, 28 adult male mice BALB/c, were divided into four groups; includes a control group and three experimental groups. TiO2 nanoparticles (in concentrations of 50, 100 and 300 mg/Kg) were administered orally to mice for 14 days. Hematological and serum parameters were studied in the collected blood samples. The results showed that all doses of TiO2 nanoparticles increased significantly white blood cells level compared with the control group but the number of red blood cells decreased. Hemoglobin, MCV and neutrophils at concentration of 300 mg/kg showed significant increase but platelets, hematocrit, lymphocytes, glucose and creatinine significantly decreased (p<0.05). Findings showed that TiO2 nanoparticles cause harmful effects on the hematological and serum parameters in mice in a dose-dependent manner.