Serum Homocysteine Level and Lipid Profile in Migraine Patients Treated with Sodium Valproate
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
Long-term treatment with sodium valproate affects the lipid profile and serum homocysteine level. Studies have revealed different results in epileptic patients and there is very little data available regarding the effects of sodium valproate in serum homocysteine level and lipid profile in migraine patients.
Objectives
The present study investigated the serum homocysteine level and lipid profile of migraine patients before and after sodium valproate prophylactic therapy.
Methods
This study included 52 adult patients with migraines who were candidates for prophylactic migraine treatment by sodium valproate. None of the patients were affected by hyperlipidemia syndromes, cardiovascular disease, stroke, diabetes, gout, carotid stenosis, hypertension, and thyroid, metabolic, or hepatic disorders. The initial peripheral venous blood sample was collected before receiving sodium valproate. Patients received sodium valproate 500 mg daily. The second venous blood sample was taken 3 months later, during the treatment period. Serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL), triglyceride (TG), high-density lipoprotein cholesterol (HDL), and homocysteine were measured by standard methods.
Results
The mean serum levels of TC, HDL, TG, and homocysteine increased significantly three months after treatment with sodium valproate. The mean serum level of LDL increased after treatment, however, the difference was not significant.
Conclusions
Sodium valproate increases the level of serum lipids in patients with migraines; therefore, the risk of cardiovascular diseases may increase by the long-term use of this drug as a prophylactic treatment in migraine patients. Consequently, in patients with other risk factors of cardiovascular disease, sodium valproate should be prescribed with caution.
Language:
English
Published:
Archives of Neuroscience, Volume:6 Issue: 1, Jan 2019
Page:
3
magiran.com/p1960056  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!