Characterization of 68Ge/68Ga Generator and Quality Control of its Eluate

Nowadays, due to the suitable decay characteristics and possible production of 68Ga independent of the cyclotron in the form of 68Ge/68Ga generator with reasonable cost, this radionuclide is known as a suitable choice for PET imaging. Recently, SnO2 based 68Ge/68Ga generator was successfully prepared in Iran. In this study, in order to investigate the possible utilization of the made generator in the production and development of 68Ga-based diagnostic radiopharmaceuticals and optimal usage of the generator in the clinical applications, the main characteristics of the generator including the selection of appropriate eluent, elution profile and elution yield were determined, and radionuclidic, chemical and radiochemical purity of the eluate were evaluated. The results of this study indicated that the characteristics of the developed generator in Iran is comparable to those 68Ge/68Ga generators in other countries and it has suitable performance for the usage of developing 68Ga-based PET radiopharmaceuticals.