The Effect of Six Weeks' Interval Training on Tumor Volume and Adipose and Muscle Tissue Levels of Adiponectin and Leptin in Breast Cancer Bearing Female Mice

Cachexia is one of the main cancer Complications. Changes in adipokines levels such as leptin and adiponectin have effective role in accelerating and slowing down of Cachexia process. Exercise training is effective strategy to combating with cachexia. However, the involving mechanism is unknown. In this context, the aim of present study was to investigate the effect of six weeks' interval training on muscular and adipose tissue levels of adiponectin and leptin in mice's with breast cancer. For this purpose, 20 female Balb/c mice with 6-8 weeks' age and means weight 14-15g, almost 10 days after Cancerous with cell line injection, assigned in two control and interval group. Mice's in interval training group performed 10 intervals (two min) with 70 percent of Vmax and immediately performed two min active recovery with 50 percent of Vmax. This training program continued for six weeks and performed with five sessions in week. Finally, visceral adipose tissue and Gastrocnemius muscle was removed and given factors was determined with ELISA method. Tumor volume measured with digital caliper. For data analyze the independent t test were used. Results indicated significant increase in adipose tissue adiponectin (P=0.013) and decrease of leptin in muscle (P=0.025) and adipose tissue (P=0.000). furthermore, decrease muscle atrophy and decrease tumor volume in exercised group observed. it seems that positive effectiveness of exercise training in decrease muscular wasting of cancerous subjects is related to modify adipokines levels such as leptin and adiponectin.