The effect of endurance training and adenosine consumption on the a1ar gene expression in the visceral adipose tissue of obese male rats

Although obesity is becoming epidemic all around the world, the effort to reduce its prevalence has not been effective. Thus, there is a need to find further paths to prevent obesity. The aim of this study was to determine the effect of endurance training and adenosine on the A1AR gene expression in the visceral adipose tissue of obese male rats Twenty wistar strain male rats were fed with high-fat food for twelve weeks and reached the average weight of 319+-30 grams. The rats were divided randomly into four groups after being conformed. The exercise training session included running on the treadmill with no slope for 12 week. Each week, five sessions were held for 15-31 minutes with the speed of 20-25 meters per minute. In order to measure the relative gene expression of A1AR, the PCR method was used. The data was analyzed using the statistical method of two-way analysis of variance. both variable of endurance training and adenosine consumption (independently) demonstrated a significant decrease in the A1AR gene expression in the visceral adipose tissue. (P=0.001). Also, the intraction of training and adenosine affects significant reduction of the A1AR expression. Endurance training and adenosine are strong stimulants of adipose tissue lipolysis as A1AR antagonists and have the potential to be used as effective lipolysis agents in obesity