Determination of Aspartate Aminotransferase Aactivity in Crervicular fluid in Gingivitis

Aspartate aminotransferase is present in gingivial Crevicular fluid, and there is preliminary evidence that its activity may correlate with the extent of gingival inflammation and tissue destruction. Method & Mateial: This work describes a study in which AST was monitored over a one year in 96 Patients with moderate adult periodontitis. Values for plaque index, gingival index and probing attachment level were recorded, and 30- second 3min samples of gingival fluid harvested. As partate aminotransferase activity was determined by a standar method. Our results showed that Aspartate aminotransferase activity in control group was 432.7526.82 and in patient group was 763.4253.27 unit/min/ ml of GCF. Aspartate aminotransferase activities of 500 units in min in ml of GCF or higher appeared to be associate with active disease. Aspartate aminotransferase activity in GCF is strongly related to human periodontal disease. Our results showed that Ast, as a direct measure of tissue damage, will prove to be useful odjunct in the diagnosis of active periodontitis and ultimately aid in the design of more effective therapy.