Investigation the Effect of Valproate on Locomotor Activity, Balance, Lipid Profile, and Serum Biochemical Parameters before Sexual Maturity in Rat
Valproate as an effective antiepileptic drug is used for the treatment of partial and generalized seizure in adults and children. This medication causes biochemical changes in liver functions and behavioral changes in childhood. Therefore, this study evaluated the effects of valproate on locomotor activity, balance, hepatic enzymes, and serum lipid profiles in immature female rats.
Materials & Methods
Postnatal female rats (23 days) were divided in two groups. The first group received valproate (200 mg/Kg/day) for two weeks and the second received saline. All injections were performed intraperitoneally. Locomotor activity and balance were evaluated using open field and rotarod apparatus, respectively. Subsequently, cholesterol (HDL, LDL, TC), triglyceride (TG), SGOT and SGPT enzymes in serum were measured.
Valproate decreased motor activity and increased hepatic enzymes (SGPT) and alkaline phosphatase. However, it had no effect on balance and serum lipid profiles.
Discussion & Conclusions
Subchronic injection of valproate has probably no effect on serum lipid profiles while increasing serum hepatic enzymes and reducing locomotor activity. Therefore, it seems that side effects of valproate occur with its long-term administration.
Article Type:
Research/Original Article
Ilam University of Medical Science, Volume:27 Issue:1, 2019
95 - 103  
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