Genomic Scan of Selective Signature in Kurd Horse

The selection of useful mutations in some populations will leave footprints at the genome level. Because of the link between these regions and important economic traits, genomics is one of the important issues in animal genetic research. The aim of this research is to identify regions of the genome which carrier signature of selection in Kurd horse using 70kb SNP markers. 28 horses selected from the different area of Kurdistan and Kermanshah, after collected sample, DNA extracted, they were genotyping. To detect footprint of signal selection, extended haplotype homozygosity (EHH) and integrated Haplotype Score (iHS) was used. The using of iHS statistics, 9 genomic regions on chromosomes 5,7,11 and 15 as regions candidate of footprint selection, identified. For the detect effect of selection on this region, used of EHH as well as investigate of bifurcation diagram of haplotype and LD. In order to evaluate the possible genes and QTLs in selected candidate regions, used of the horse SNP databases (HSDB) and the QTL of the animals. The regions on 7 and 11 chromosomes were observed as candidate positive selection while in other regions (chromosomes 5 and 15), notwithstanding allele frequency, it wasn’t affected positive selection so these alleles were the common and old alleles. In these regions, a number of genes and QTLs were identified that are active in the muscle, immune system and intracellular activity. Therefore, these genomic regions of Kurd horse, probability were targeted positive selection.