Effect of Polyethylene Glycol and Senna Bowel Preparation in Dogs on Some Hematological and Serum Biochemical Parameters
Message:
Abstract:
Background
Colonoscopy is the preferred procedure for diagnosis of large-bowel diseases in dogs. Polyethylene glycol (PEG) is the most commonly used laxative for colonic cleansing. Senna has been used in traditional medicine as a laxative and an aid to treat constipation.
OBJECTIVES
The aim of this study was to evaluate the safety of senna as an alternative or adjunct to polyethylene glycol solution in dogs using hematology and biochemistry.
METHODS
For this purpose, 20 mongrel dogs were randomly allocated to receive 1 of 4 different bowel preparation regimens including PEG, senna or their combinations plus enema. Serum concentrations of sodium, potassium, total calcium, phosphorus, chloride, magnesium, PCV, total protein, ALT, AST, BUN and creatinine were measured at 0, 1, 2, 5, 6 and 24 hours after the first ingestion of laxative solutions.
RESULTS
Statistical analysis showed that PEG or senna solutions had no significant effect on serum concentration of the evaluated parameters (P>0.05). Despite the significant changes in serum concentration of all measured parameters based on time of sampling in all groups, they were in their normal ranges (P>0.05).
CONCLUSIONS
This is the first evaluation of the safety of bowel preparation with senna in dogs. This study showed that the use of PEG and senna for colon cleansing in dogs did not have any deleterious effects on their serum biochemical and electrolytes concentration.
Article Type:
Research/Original Article
Language:
English
Published:
Iranian Journal of Veterinary Medicine, Volume:13 Issue:2, 2019
Pages:
175 - 185
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