The effect of nettle and fenugreek seed extracts on diabetic mice

To evaluate the effect of nettle and fenugreekseed extracts on glucose, lipid parameters and total anti-oxidative capacity, 40 male NMRI streptozotocin induced diabetic mice arranged in five groups. The treatments were included of 10 daily injectional metformin, seeds extracts of nettle and fenugreek and their combination in 1:4, 2:4 and 3:4 proportions, along with positive and negative controls. After 48 hours of last injection, glucose, cholesterol, LDL, HDL, and TAC were measured via intraventrecular blood sampling. Ecperimental treatments, especially combinational seed extracts of nettle and fenugreek in 2:4 proportion depressed blood glucose rate. Combinational extracts of 1:4 significantly decreased cholesterol rate, however, metformin and nettle seed extract increased it. Nettle seed extract and combinational extracts decreased and increased LDL, respectively. Metformin, nettle seed and combinational 2:4 extracts increased TAC. Therefore, studied extracts could be a candidate for diabetes cure and its side-effects reduction.