Association of IL-1 and TNF-α Levels in Endometrial Secretion and Success of Embryo Transfer in IVF/ICSI Cycles
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Objective
Since some cytokines such as IL1 and TNFα are factors involved in endometrial receptivity ,we have determined the amount of these two factors in endometrial secretion in the eligible individuals and then, study their relationship with the success or failure of pregnancy in IVF/ICSI cycles. Methods & Materials:  In this non-randomized descriptive study, 76 women selected for their first IVF/ICSI met the study inclusion criteria. All the patients underwent endometrial secretion aspiration prior to oocyte collection. The level of IL-1and TNF-α were analyzed by enzyme-linked immunosorbent assay method using special standard kits. To detect successful implantation and pregnancy patients underwent serum human chorionic gonadotropin measurements and ultrasound evaluation.
Results
Of the 76 subjects under study, 33 (43.4%) had positive βHCG and 44 (56.6%) had negative BHCG. Of the patients with positive βHCG, 23 (30.3%) had fetal heart rate in their TVS. Comparison of cytokine levels showed higher concentration of IL1 in the group with successful chemical pregnancy compared to the group with failed pregnancy (p=0.00). However, no significant difference in terms of clinical pregnancy was revealed in IL-1 levels between two groups (p=0.06).when considering TNFα there was no significant difference in the level of TNFα between the two groups either in terms of chemical or clinical pregnancy.(P=08and .0.6 respectively).
Conclusion
The current study suggested that higher concentrations of IL-1 in endometrial secretions might be associated with improved endometrial receptivity and IVF outcome. Regarding TNFα no statistically significant differences were seen between the groups with and without successful pregnancy.
Language:
English
Published:
International Journal Of Fertility and Sterility, Volume:13 Issue: 3, Oct-Dec 2019
Pages:
236 to 239
magiran.com/p2001205  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!