Solitary rectal ulcer syndrome: addition of rectal therapies to biofeedback is more effective than biofeedback alone

We designed this study to evaluate the effectiveness of the combination of topical rectal therapy with biofeedback in treatment of solitary rectal ulcer compared to single biofeedback therapy. Biofeedback therapy is an appropriate treatment for patients with solitary rectal ulcer syndrome (SRUS) but it seems that it is not effective alone. Topical medical therapies are supposed to have an additive role to biofeedback. This randomized, controlled trial was conducted on 63 patients with SRUS. Patients were randomly enrolled into two groups of combination and single therapy. The patients in combination group (n=31) received biofeedback plus a topical therapy (an enema contained dexamethasone, sulfasalazine and bismuth) and the patients in single therapy group (n=32) were treated with biofeedback alone. Endoscopic responses to treatment in the combination and single groups were 80% and 50%, respectively (P<0.05).  Clinical improvement in symptoms such as difficulty to evacuate, digitation to evacuate, feeling of incomplete evacuation, time to need to evacuation and life style alternation were significantly better in treated group by combination therapy than single therapy. Regarding to the mean total score based on all subjective parameters, the results were also significantly better in the treated group by combination therapy. Topical anti-inflammatory therapies in combination with biofeedback is an efficient treatment for patients with SRUS.Keywords: Biofeedback, SRUS, Endoscopic responses.(Please cite as: Abdi S, Tavakolikia N, Yamini M, Bagheri M, Sadeghi A, Pourhoseingholi MA, et al. Solitary rectal ulcer syndrome: addition of rectal therapies to biofeedback is more effective than biofeedback alone. Gastroenterol Hepatol Bed Bench 2019;12(3):197-202).