Improvement for rapid diagnosis of cervical cancer (Intra-epithelial) based on Human Papilloma Virus type 16 and 18 using electrochemical biosensor

Human papillomavirus (HPV) is one of the most prevalent sexually transmitted viruses. HPV types 16 and 18, as the most common high-risk HPVs, cause malignant changes and cervical cancer. Since common diagnostic methods have many disadvantages, the development of novel diagnostic methods can be very promising as a useful tool with high speed and efficiency, as well as cost-effective. Electrochemical biosensors as new tools have advantages such as a wide range of diagnostics, low cost and simple laboratory equipment. This review study was performed with aim to present a summary of the development of electrochemical biosensors to diagnose HPV types 16 and 18. In this study, English and Persian articles were searched in scientific databases of Pubmed, Cochrane Library, Scopus, Science Direct, Goggle Scholar and two Iranian databases of SID and IranMedex using Mesh keywords from 2003 to 2008. In this study, we investigated the role of electrochemical biosensors in early diagnosis of HPV type 16 and 18 by using the published articles in scientific literature. A total of 11 articles were studied. By analyzing the newest electrochemical biosensors for diagnosis of HPV, we observed that the sensor platform developed by Wang et al. showed the lowest detection limit (1 Atto molar). The electrochemical biosensor with high sensitivity can be used as a suitable method.