Effects of Rosa canina L. against ethanol induced hepatotoxicity and nephrotoxicity
Message:
Abstract:
Background
Rosa canina L. widely used in Iranian traditional medicine. This study was designed to assess the protective activity of ethanol extract of RC in ethanol-induced hepatotoxicity in rats.
Materials and methods
In our study, 30 male Wistar rats were divided into 5 groups: control, ethanol (5 g. kg−1), ethanol (5 g. kg−1) + RC1 (200 mg. kg−1), ethanol (5 g. kg−1) + RC2 (400 mg. kg−1) group and RC (400 mg. kg−1). Histopathological evaluation, measurement of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), blood urea nitrogen (BUN) and creatinine levels were performed.
Results
Ethanol consumption caused a significant increase in the serum levels of AST, ALT, ALP, BUN and creatinine. Co-administration of RC (200 and 400 mg/kg/d) with ethanol, significantly decreased levels of ALT, AST, ALP, BUN and creatinine. The extract (200 and 400 mg/kg/d) ameliorate the histological injuries compare to ethanol group.
Concludion
Our findings suggest a hepatoprotective and renoprotective capability of RC extract against ethanol induced alteration in biochemical and histopathological properties of hepatic and renal tissues.
Article Type:
Research/Original Article
Language:
Persian
Published:
Journal of Animan Researches, Volume:31 Issue:4, 2019
Pages:
498 - 510
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