Transplant nephrectomy; pathological features of 124consecutive cases in a single center study over 10 years
Author(s):
Article Type:
Research/Original Article (بدون رتبه معتبر)
Abstract:
Background
Transplant nephrectomy (TN) is not commonly performed but it may be essential for several indications.Objectives
This study details an in-depth evaluation of the histological changes present in TN specimens.
Patients and Methods
Results
In AGL group, most cases showed no tubulointerstitial inflammation, interstitial fibrosis and tubular atrophy, but 74.5% had necrosis. All cases in Rej/GIS group showed severe interstitial fibrosisand tubular atrophy, since 40.9% showed severe tubulointerstitial inflammation. Glomerulitis was observed in 52.3% and transplant glomerulopathy (TG) was detected in 75.0%. Arteritis of
intrarenal arteries and the MRA were detected in 70.5% and 59.1%. In INF group, 66.7% had tubulitis and 79.2% had interstitial inflammation with lymphocytes, and severe interstitial fibrosis
while, tubular atrophy were detected in 66.7%. TG was detected in 62.5%. In MIS group, the
histological changes were minor.
Conclusions
This study provides a detailed description of the morphological characteristics associated with various indications for TN. TN will occasionally reveal unexpected and significant
findings
that may require specific forms of treatment to manage the patient appropriately.Keywords:
Language:
English
Published:
Journal of nephropathology, Volume:8 Issue: 3, Jul 2019
Page:
2
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