Anti-tumor activity of Fe (III), Co(II) and Pd(II) complexes of N3-{phenyl [(4-pyridylcarbonyl)amino]methyl}

An anti-tumor compound as N3-{phenyl [(4-pyridylcarbonyl) amino] methyl} weresynthesized and identified (NPPA). Fe (III), Co(II) and Pd(II) metal complexes of this ligand preparedby reaction of chloride salt of Fe (III), Co(II) and Pd(II) with NPPA in dry acetonitrile. Identification andCharacterization of the ligand was performed by FT-IR, 1H-NMR spectroscopy and elemental analysisand all complexes were characterized by several techniques using elemental analyze (C, H, N), FTIR,1H-NMR (except Co complex), electronic spectroscopy and molar conductance measurements.These new compounds were used to biological studies; and its anticancer properties against the twotypes of cancer cells such as k562 (human chronic myeloid leukemia) and Jurkat (human T lymphocytecarcinoma) was revealed. The results of in vitro activities were very interesting and promising. Theseresults showed that complexes offer a new outlook for chemotherapy. It should be noted that the resultssuggest that complex showed greater effects than ligand.

International Journal Of Bio-Inorganic Hybrid Nanomaterials, Volume:7 Issue:3, 2018
205 - 211  
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