The Effect of Six-Week Continuous and High Intensity Interval Aerobic Training before Cerebral Ischemia on spatial memory and BDNF level in Hippocampus Male Wistar Rat’s

Pre-conditioning with physical activities reduces brain injuries caused by stroke. However, the effect of aerobic continuous and interval training on memory has not been measured after stroke. Therefore, the aim of this study was to investigate the effect of six weeks continuous and High intensity interval training before stroke on spatial memory and hippocampus BDNF levels in wistar rat brain. For this purpose, seventy-five 12-weeks-old wistar rats were randomly divided into three groups including Control (N=25), Moderate continuous training (N=25) and High intensity interval training (N=25) to do the moderate continuous (5 sessions per week) and the high-intensity interval (3 sessions per week) for six weeks. The acquisition of spatial memory was done for 3 days after 48 hours after the last training session and the surgery of cerebral ischemia was conducted after 24 hours. Then spatial memory test was taken after seven days later. Immediately after test, animals were anesthetized for measuring hippocampus BDNF levels. ANOVA results revealed MCT decrees destruction in memory and learning (P = 0.0002). In addition, Kruskal-Wallis statistical test indicated, that MCT increased the BDNF levels in the hippocampus rather than HIIT (P = 0.02). Moderate intensity continuous training plays a significant effect on preventing memory loss, learning, and the BDNF amount of hippocampus after brain stroke. Indeed, MCT can reduce brain tissue injuries that are cause of the brain stroke.