The effect of 4 weeks High-Intensity Interval Training (HIIT) on the content of PPARγ and PRDM16 in adipose tissue of diabetic obese male rats

Today, important proteins and pathways have been identified that lead to the regulation of the white adipose tissue and converting it to brown adipose tissue, the proteins PPARγ and PRDM16 are key proteins in this setting. Diabetes is one of the major causes of obesity and complications that can interfere in the function of these two proteins. This study aimed to investigate the effect of 4 weeks High-Intensity Interval Training (HIIT) on the content of PPARγ and PRDM16 proteins in subcutaneous adipose tissue of diabetic obese male rats.

In this experimental study, 16 Sprague-Dawley male rats (mean weight of 300±20 gr) were selected and after induction of diabetes by injection of STZ and nicotinamide was randomly assigned into two groups: diabetic training and diabetic control. The experimental group performed HIIT training for 4 weeks, accordance with the training program for 4 weeks, while the control group did not have any training program. Independent T-test was used to analyze the data.

Significant change was not observed in the content of PPARγ (P=0.16) and PRDM16 (P=0.83) proteins in HIIT training group compared to the control group.

According to the results of this study, HIIT training has not led to significant change the content of PPARγ and PRDM16 proteins. It seems to the intensity of HIIT training be a major contributor to the result that should be taken into consideration.