Curcumin Improves the Efficacy of BMSCs in Myocardial Ischemia Injury in Rat
Message:
Abstract:
Background

Myocardial infarction can be associated with irreversal myocardial ischemia and the necrosis of the affected site of the heart. Curcumin has a protective effect on Myocardial Ischemia.

Objectives

Our study aimed to combine a regenerative medicine with a traditional antioxidant effects as an adjuvant for the treatment of isoproterenol-induced MI.

Methods

This experimental study conducted on 36 adult male Wistar rats in an university-affiliated animal lab, Urmia, Iran, in 2016. Male rats were divided into six groups of six rats, including control, MI (ISO 100 mg/kg), curcumin (80 mg/kg by oral gavage), Bone Marrow Mesenchymal Stem Cells (BMSCs; 4 × intravenous injection), and Cur-BMSCs. The efficiency of these methods was evaluated by histopathological examination, immunohistochemistry, measurement of heart rate, heart to body weight ratio, size of infarction, and serum levels of CK-MB, LDH, MDA, and SOD.

Results

The benefit of curcumin was apparent in two recipient groups. The rats that received curcumin or were treated with BMSCs showed significant reductions in heart to body weight ratio (P < 0.001). The elevation of serum levels of CPK, LDH, MDA, and SOD (P < 0.001) was done in curcumin treatment groups. Decreases in the number of apoptotic cells were significant in cur (P < 0.001) and cur-BMSCs (P = 0.023) groups; histopathological injuries were recognized significantly in cur (P < 0.001) and cur-BMSCs (P = 0.012) groups, and infarct size was significant in both curcumin groups (P < 0.001).

Conclusions

Curcumin pretreatment of Bone Marrow Mesenchymal Stem Cells helps in stem cells transplantation and acts as a synergist.

Article Type:
Research/Original Article
Language:
English
Published:
Iranian Red Crescent Medical Journal, Volume:21 Issue:9, 2019
Page:
6
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