Effects of Rosa canina fruit hydroalcoholic extract on lipid profile and liver enzymes level in diabetic mice

This study was aimed to investigate the effects of Rosa canina (RC) fruit hydroalcoholic extract on lipid profile and liver anzymes level in diabetic mice.

 Ninty-six male mice were divided into 4 groups. The normal and diabetic groups received normal saline (p.o., 0.5 ml), however RC and RC-treated diabetic groups received RC hydroalcoholic extract (p.o., 500 mg/kg). Diabetes was induced by a single dose of streptozotocin (STZ) (i.p., 200 mg/kg) and 10, 20, and 30 dayes after diabetes induction the lipd profile (cholesterol, triglyceride, LDL, HDL and VLDL) and liver anzymes (ALP, ALT and AST) were evaluated.

Glucose level in the diabetic groups significantly(p<0.01) increased compared with the control group. Administration of the extract in the diabetic group resulted in significant reduction(p<0.01) in LDL, VLDL, triglyceride and cholesterol levels in comparison with diabetic animals. Administration of the extract in the diabetic group significantly increased (p<0.05) HDL level and decreased (p<0.01) ALT and AST levels.

RC fruit extract has the regulatory role in controlling lipid profile and liver anzymes level in mice models of diabetes.