Effect of four weeks aerobic training on Endothelin-1 and ANP in obese women

Obesity and physical inactivity lead to cardiovascular disease. The purpose of this study was to investigate the effect of four weeks' endurance training and aerobic movements on ANP and Endothelin-1 in obese women.

Subject was included 19 obese women (mean age: 27.94± 3.3 year), (mean weight 85.4±5.12 kg), (mean height: 163.00± 4.91 cm), (mean BMI: 32.28±2.82 kg/m2) that were randomly allocated to experimental (n=9) and control groups (n=10). The experimental group completed a program training, which included 10 to 15 minutes of warm-up, 15 minutes of activity with ergometer and 45 minutes of aerobic movements, with an intensity of 60 to 72% of the HRmax, three sessions per week, for four weeks. Samples blood were taken after 12 hour fasting, before of start and 48 hours after end program training. ELIZA reader methods used for analysis of bio parameter and MANCOVA and ANCOVA used for date analysis in significant of P

Results showed significant differences between groups in endothelin-1 (P=0.007) but ANP changes were not statistically significant (P=0.14).

Based on research findings, four weeks of aerobic training results in reduced the function of activating system of endothelin-1 in obese women and may play a role in improving the vascular endothelial system and body metabolism in obese women.