The effect of ten weeks of high intensity interval training and continuous endurance training on the expression of MIR-205 and VEGF gene in mice with breast cancer has been compared

the effect of ten weeks of high intensity interval training and continuous endurance training on the expression of MIR-205 and VEGF gene in mice with breast cancer has been compared.

Study was done on 23 female Balb/crats with age of6 to 7 weeks and mean body mass of 20-18 g. the estrogen-dependent carcinoma cell line MC4-L2 were cultured in the culture medium. Then one million cancer cells were injected into each mouse subcutaneously. A week after tumor induction, mice were randomly divided into three groups of 6: control (C), continuous aerobic (E), interval high intensity (H). Training were done for 10 weeks, five times a week. Each session of protocol for Group E was done with the intensity of 65-60 percent vo2max and for Group H was done with an intensity of 90-85 percent vo2max . Expression levels of MIR-205 and VEGF genes were measured by Real time-PCR metho.

compared to the control group ,MIR-205 expression levels in high intensity Interval (p=0/000), and continuous endurance (p=0/001), increased significantly. And compared to control group, gene expression levels of VEGF in high intensity Interval (p=0/003), and aerobic endurance group (p=0/005), decreased significantly.

with regard to the increasing effect of High intensity aerobic Interval training and aerobic endurance training on the expression of MIR-205 and depressing effect of these mentioned training on VEGF gene expression, these two types of practice could reduce tumor growth on mice with breast cancer.