Optimization of Natural Rhenium Irradiation Time to Produce Compositional Radiopharmaceutical
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Introduction
Previously, 186Re and 188Re radioisotopes have been produced through appropriate activities, and each of them has been used for therapeutic applications. The 186Re and 188Re have unique properties, which make them proper for the treatment of tumors in different sizes. The long-range 188Re, is suitable for the annihilation of large tumors. In contrast, the short-range 186Re is desirable for the destruction of small tumors. The aim of this study was to find the suitable time for rhenium irradiation in order to simultaneously produce radionuclides with both appropriate and identical activities.Material and Methods
To reach 186Re and 188Re with appropriate activities to produce compositional radiopharmaceutical, we have investigated natural rhenium irradiation at different times to produce 186Re and 188Re simultaneously with appropriate and identical activities to reach compositional radiopharmaceutical. In this regard, the simultaneous production of 186Re and 188Re with appropriate activities were investigated analytically through natural rhenium irradiation in a reactor. The irradiation was assessed at different time intervals in order to reach appropriate activities for compositional radiopharmaceuticals.Results
On the basis of the findings, 186Re and 188Re could be produced simultaneously with suitable and almost equal activities with irradiating natural rhenium for 4 days and considering 1 day for cooling. Moreover, the obtained results of this study revealed that the generated impurities were negligible.Conclusion
The optimization of natural rhenium irradiation time can help the simultaneous production of 186Re and 188Re with appropriate activities for compositional radiopharmaceuticals.Keywords:
Language:
English
Published:
Iranian Journal of Medical Physics, Volume:16 Issue: 5, Sep-Oct2019
Pages:
362 to 367
magiran.com/p2033963
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!