The Levels of Inflammatory Markers (IL-6, CRP), Homocysteine and Lipid Profile in Hemodialysis Patients, Isfahan

Cardiovascular disease (CVD) and inflammation are among the most common causes of mortality in dialysis patients. Factors such as chronic inflammation, dyslipidemia and elevated homocysteine levels may underlie the increased risk of CVD.

This study aimed to investigate levels of inflammatory markers, homocysteine, lipid profile, WBC, and BMI levels in hemodialysis patients compared with the control subjects in Isfahan.

A total of 32 hemodialysis patients and 32 healthy subjects were selected randomly and their serum levels of IL-6, CRP, homocysteine, and lipid profiles were measured.

According to the results, most of the studied hemodialysis patients compared to the healthy subjects had non-normal amounts of IL-6, CRP, and homocysteine i.e., higher than healthy subjects (P < 0.05). Cholesterol, HDL, and LDL were significantly lower than the healthy subjects (P < 0.05), while triglycerides and VLDL levels showed no significant difference (P: 0.38 > 0.05). A significant difference of BMI was observed between the normal subjects and the patients; thus, this factor in patients was less than what was in the healthy group (P: 0.001 < 0.05).

The results demonstrated that in most patients the levels of factors IL-6, CRP, and homocysteine were abnormal compared to the healthy group. In addition, the risk of developing cardiovascular and inflammatory disease as well as dyslipidemia in these patients is higher than normal