Effect of six-weeks high intensity interval training under simulated microgravity condition on morphology of radial nerve myelin sheet in male rats

The purpose of this study is to investigate the effect of six weeks of HIIT under simulated microgravity conditions on morphological changes of radial nerve myelin sheath in male rats. In the present study, 24 male wistar rats were randomly selected and divided into four groups including: TS (training during suspension: n=6), CS (suspension: n=6), T (training: n=6), C (control: n=6). The training groups run on treadmill for six weeks (five days a week). 24 hours after the last training session, animals were prepared for tissue samples. At the end of the experiment, changes in myelin sheath were measured by Luxol fast blue. obtaining results showed that the percentage of changes in myelin sheath in HIIT group under simulated microgravity (p≤0.001) was higher than other groups, significantly (30/27+5/27). Based on the results, HIIT under simulated microgravity conditions affected on changes in myelin sheath. Therefore, it can play an effective role in the improvement of clinical status of neurological patients and decrease side effects in Astronauts.