Evaluation of the interference effect of cyclosporine and Mesobut scorpion venom on some biochemical and histological parameters in parenchymal tissue of liver and kidney of male mice

Venom of Mesobuthus in the family buthidae can result in death in humans according to the performed studies. On the other hand, it has been demonstrated that due to anti-inflammatory properties of cyclosporine in organ transplantation through suppression of the immune system and inflammation, it could counteract venom effect. Therefore, in this study, the effect of cyclosporine on Mesobuthus eupeus venom was evaluated.

This was an experimental study. For this purpose, fifty mice were classified into five groups, each group consisting of ten mice. Mesobuthus venom and cyclosporine were used at three doses of 10, 20, and 30 mg. In this study, the mice which did not receive cyclosporine were considered as control group. Biochemical features plus nitric oxide and IL-2 cytokine were measured in all groups using routine methods (i.e. spectrophotometer and ELISA assay, respectively). Also, pathological examination of liver and kidney was performed.

All the studied biochemical and IL-2 levels were significantly elevated after mesobuthus venom injection On the other hand, groups which received cyclosporine showed a significant decrease in all the studied parameters (P<0.001).

Cyclosporine at a dose of 30 mg is able to decrease inflammatory responses and it could be a suitable therapeutic drug in patients who are bitten by scorpion sting