Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in Predic-tion of Computed Tomography Findings in TraumaticBrain Injury; a Meta-Analysis
Message:
Abstract:
Introduction

Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is one of the promising candidates, with an accept-able diagnostic value for predicting head computed tomography (CT) scan findings. However, there has beena controversy between studies and still, there is no general overview on this. Therefore, the current system-atic review and meta-analysis attempted to estimate the value of UCH-L1 in predicting intracranial lesions intraumatic brain injury (TBI).

Methods

Two independent reviewers screened records from the search of fourdatabases Medline, Embase, Scopus and Web of Science. The data were analyzed in the STATA 14.0 statisticalprogram and the findings were reported as a standardized mean difference (SMD), summary receiver perfor-mance characteristics curve (SROC), sensitivity, specificity, and diagnostic odds ratio with 95% confidence in-terval (95% CI).

Results

Finally, the data of 13 articles were entered into the meta-analysis. The mean serumlevel of UCH-L1 was significantly higher in patients with CT-positive than in TBI patients with CT negative (SMD= 1.67, 95% CI: 1.12 to 2.23, I2 = 98.1%; p <0.0001). The area under the SROC curve for UCH-L1 in the predic-tion of intracranial lesions after mild TBI was 0.83 (95% CI: 0.80 to 0.86). Sensitivity, specificity and diagnosticodds ratio of serum UCH-L1 was 0.97 (95% CI: 0.92 to 0.99), 0.40 (95% CI: 0.30 to 0.51) and 19.37 (95% CI: 7.25to 51.75), respectively. When the analysis was limited to assessing the serum level of UCH-L1 within the first 6hours after mild TBI, its sensitivity and specificity increased to 0.99 (95% CI: 0.94 to 1.0) and 0.44 (95% CI: 0.38to 0.052), respectively. In addition, the diagnostic odds ratio of 6-hour serum level of UCH-L1 in the predictionof intracranial lesions was 680.87 (95% CI: 50.50 to 9197.97).

Conclusion

Moderate level of evidence suggeststhat serum/plasma levels of UCH-L1 have good value in prediction of head CT findings. It was also found thatevaluation of serum/plasma level of UCH-L1 within the first 6 hours following TBI would increase its predictivevalue. However, there is a controversy about the best cutoffs of the UCH-L1.

Article Type:
Review Article
Language:
English
Published:
Archives of Academic Emergency Medicine, Volume:6 Issue: 1, 2018
Page:
61
magiran.com/p2040693  
برخی از خدمات از جمله دانلود متن مقالات تنها به مشترکان مگیران ارایه می‌گردد. شما می‌توانید به یکی از روش‌های زیر مشترک شوید:
اشتراک شخصی
در سایت عضو شوید و هزینه اشتراک یک‌ساله سایت به مبلغ 400,000ريال را پرداخت کنید. همزمان با برقراری دوره اشتراک بسته دانلود 100 مطلب نیز برای شما فعال خواهد شد!
پرداخت با کارتهای اعتباری بین المللی از طریق PayPal امکانپذیر است.
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی همه کاربران به متن مطالب خریداری نمایند!
توجه!
  • دسترسی به متن مقالات این پایگاه در قالب ارایه خدمات کتابخانه دیجیتال و با دریافت حق عضویت صورت می‌گیرد و مگیران بهایی برای هر مقاله تعیین نکرده و وجهی بابت آن دریافت نمی‌کند.
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.