Introducing Genes With Significant Role in Migraine: An Interactomic Approach
Message:
Abstract:
Introduction

Migraine is a severe kind of headache with the chance hereditary of 50%. Molecular studies can promote understanding of migraine pathophysiology. One of which is bioinformatics approach that could provide additional information related to the identified biomarkers. 

Methods

In this research, migraine genes are studies in terms of interaction pattern to introduce important individuals. Through STRING database Plug-in in Cytoscape, candidate genes for migraine were retrieved and analyzed by related applications. Based on centrality and action types (expression, activation, and inhibition) genes were screened.  

Results

Numbers of 33 central genes including seven hub-bottlenecks were identified which 70% of central genes were involved in expression action with each other. Activation was dominate action relative to inhibition between the central genes.

Conclusion

The finding indicates that insulin is the most important gene relative to migraine. It seems regulation of metabolism play critical role in control of migraine.

Article Type:
Research/Original Article
Language:
English
Published:
Basic and Clinical Neuroscience, Volume:10 Issue:4, 2019
Pages:
363 - 372
magiran.com/p2041196  
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