Exercise Training Enhances Expression of Tropomedulin-2 and ADP-Ribosylation Factor 6 in the Cerebellum of Male Wistar Rats
Message:
Abstract:
Background

It has been well documented that exercise training (ET) induces beneficial effects on the central nervous system (CNS); however, the underlying mechanisms are less known. We presumed that actin cytoskeleton regulatory proteins such as ADP-ribosylation factors 6 (ARF6) and tropomodulin 2 (TMOD2) may be important elements of Exercise-Induced Neuroplasticity (EIN). We evaluated this hypothesis in the present study.

Methods

We randomly divided 12 male Wistar rats into control (C) and training (T) groups. The T group was exposed to six weeks of moderate-intensity treadmill running. The ARF6 and TMOD2 gene and protein expressions in the cerebellum of male Wistar rats were assessed by the real-time PCR and western blot analysis.

Results

The results showed that TMOD2 and ARF6 gene and protein expressions were significantly higher in the T group than in the C group.

Conclusions

It seems that chronic treadmill running increases TMOD2 and ARF6 gene and protein expressions in the cerebellum and these changes probably lead to the improvement of brain function.

Article Type:
Research/Original Article
Language:
English
Published:
Zahedan Journal of Research in Medical Sciences, Volume:21 Issue:4, 2019
Page:
4
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