The Role of Matrix Metalloproteinase-2 Expression in Gastric Cancer Susceptibility: A Systematic Review

Gastric carcinoma (GC) is the most commonly diagnosed cancer that has been one of the main causes of cancer death worldwide. The matrix metalloproteinase-2 (MMP2) gene was expressed in the gastric cancer tissues compared to the matched normal tissues that are associated with the metastasis of gastric cancer cells.

This systematic review was performed to investigate the role of MMP-2 in gastric cancer among the different population.
Evidence Acquisition: We searched on electronic databases such as PubMed, Scopus, Science Direct and Cochrane Library Database without any language restriction for relevant publications which were published until April 2019.

Thirty two original and relevant studies that evaluate the association between gastric cancer and MMP-2 were included. This systematic review indicated that increased MMP-2 expression has been seen in gastric cancer. MMP-2 over-expression may play a crucial role in degrading extracellular matrix as well as stimulate angiogenesis.

MMP2 over-expression can play a critical role in tumor metastasis, tumor size, invasion, and lymph node invasion in GC