Evaluation of Polymer-based Drug Delivery Systems in Preventing AIDS

Technological advances in the field of novel polymeric drug delivery systems havebeen formulated with long-term releases. Such formulations are a great method forchronic diseases, especially when the lack of compliance may be effective in responding totreatment. New drug delivery systems have provided an opportunity to overcome many ofthe challenges associated with the treatment of AIDS through anti-retroviral drugs (ARVs)and thus improving patients with AIDS. In this paper, a comprehensive review of thedifferent polymeric systems for release of ARVs to achieve its sustained release kineticshas been addressed. Potentialities of different systems and routes for administration of ARVdrugs, such as transdermal, buccal and rectal delivery have been studied. Physico-chemicalproperties, in vitro and in vivo performance such as sustained release from tablets, ceramicimplants, polymer nanoparticles, nano reservoirs, liposomes, polymer mixture, emulsions,microemulsions, nanopowders and etc are summarized. Increasing awareness aboutpolymeric systems that cause the long-term release of ARVs will facilitate the developmentof this strategy to achieve potential benefits. This review shows the significant potential ofnovel polymeric drug delivery systems and polymer inhibitors used to treat AIDS patientseffectively with future ARVs.