Preparation and Evaluation of Eudragit® L100 Nanoparticles LoadedImpregnated with KT Tromethamine Loaded PVA -HEC Insertions forOphthalmic Drug Delivery

The purpose of the present study was to improve the ocular delivery for ketorolactromethamine (KT) used to treat inflammation of the eye.

Eudragit nanoparticles loaded with KT were prepared and incorporated in polyvinylalcohol (PVA) and hydroxyethyl cellulose (HEC) films. Nanoparticles were characterized byFourier transform-infrared (FT-IR), scanning electron microscopy (SEM). Physicochemicalproperties and encapsulation effciency were investigated for nanoparticles. Also, the insertswere evaluated for their physiochemical parameters like percentage moisture absorption,percentage moisture loss, thickness and folding endurance.

Mean particle size and zeta potential were in range of 153.8-217 nm and (-10.8) -(-40.7) mV, respectively. The results show that the use of a surfactant has not led to any majorchange on drug loading. The loading increases with the amount of polymer. The insert had athickness varying from 0.072 ± 0.0098 to 0.0865 ± 0.0035 mm. The thicknesses of the insertsand the folding endurance increased with the total polymer concentration. The physicochemicalproperties showed that the Eudragit® L-100 nanoparticles loaded PVA-HEC films could be aneffective carrier for KT.

For the first time, inserts of Eudragit nanoparticles were successfully prepared forophthalmic drug delivery system to prevent frequent drug administration and enhance patientcompliance.