Evaluation of association between polymorphism of proxisome proliferator-activated receptor-α and coronary artery calcification in coronary artery disease patients
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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Introduction
In previous studies the association between PPARα gene polymorphism and coronary artery calcification (CAC) CAD and atherosclerosis have been demonstrated and, CAD has been shown to be a directly related to CAC. However, an association between PPARα gene polymorphism and CAC has not been studied in our population. The aim of this study was to evaluate a possible association between PPARα gene polymorphisms and  CAC  in CAD patients.
Materials and Methods
A total of Ninety CAD patients and 90 controls enrolled in this study. Computed tomography (CT) angiography was performed for all subjects and CAC was analyzed in the left coronary, left main coronary, right coronary and circumflex arteries. Polymorphism of PPARα was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and possible associations between PPARα polymorphism and coronary artery calcification in CAD patients and healthy controls were investigated.
Results
No significant differences in the allele frequencies (G, C) or genotypes (GG, GC) were found between the two groups (G = 84.6% vs. C = 15.4%; P = 0.52) and (GG = 70.1% vs. GC = 28.9%; P = 0.43), respectively. No significant differences were found between genotype or allele frequencies in patients or healthy control with different CAC (P = 0.41).
Conclusion
No significant association was found between allele – genotype frequencies in subjects with CAC.
Language:
Persian
Published:
Medical Journal of Mashhad University of Medical Sciences, Volume:62 Issue: 2, 2019
Pages:
1420 to 1429
magiran.com/p2047967  
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