Predictors of peritoneal dialysis associated peritonitis;application of the zero-inflated negative binomial model
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Article Type:
Research/Original Article (بدون رتبه معتبر)
Abstract:
Introduction

Peritonitis is the main cause of morbidity and dropout from peritoneal dialysis (PD)
program.

Objectives

We aimed to determine risk factors predisposing to PD-associated peritonitis.

Patients and Methods

As a retrospective cohort research, on 235 PD individuals with 4277 patientmonths of follow up, 170 episodes of peritonitis was reported in 93 patients. Data were extracted from medical records using a template. Standard as well as zero-inflated negative binominal regression was used to model the association between patients’ characteristics and the peritonitis rate. Cox-proportional hazard (PH) adjusted model was used to determine the effect of factors on the peritonitis-free survival.

Results

With a mean (SD) body mass index (BMI) of 18.7(3.4) kg/m2, 109 (46.4%) of them weremale. With a median (95% CI) follow-up time of 19 (16 to 36) months, the rate of peritonitis was0.48 episode per patient-year. The most common micro-organism detected was coagulase-negativestaphylococci (n=54; 31.7%). The only variable which was associated with a higher rate of peritonitis
was BMI (rate ratio [RR]: 1.07; 95% CI 1.01 to 1.14; P value=0.031). Comparing to patients with lower education, patients with higher than elementary school of education had higher peritonitisfree survival (with hazard ratio [HR]=0.51; 95%CI 0.33-0.79, P value=0.003) and higher chance of having no peritonitis [odds ratio (OR):1.97; 95% CI 1.08 to 3.59; P value=0.029].

Conclusion

Peritonitis is still a major concern in PD patients. BMI was a risk factor for higher peritonitis rate. Higher education level was associated with lower peritonitis-free survival and higher chance of having no peritonitis.

Language:
English
Published:
Journal of nephropathology, Volume:8 Issue: 4, Oct 2019
Page:
2
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