High costs of treatment and rehabilitation lead to increased tendency of researchers using the natural and cheaper compounds. Sheep visceral fat contains various types of fatty acids with. anti-inflammatory and therapeutic effects for wound healing. The aime of this study is to investigate the effect of visceral fat treatment on wound healing in male rats .
In this experimental study 50 adult male Sprague-Dawley rats with the relative weight of 250-300 g were selected.All rats were randomly divided into 2 groups with 25 rats in each grupe, treated with 10ml melted visceral fat, and control group asses then full thickness excisional wounds on the back skin under surgical anesthesia., respectively. The of evaluation of the wound size was investigated by imaging using an accurate caliper and Image J software. On days 5, 10, 12, 15 and 21, tissue biopsy from both control and treatment groups was performed to compare wound healing factors. The biopsy sample at21th day was check the amount of hydroxyproline precipitate in tissue. Finally, the results were compared by one way ANOVA and Tukey tests.
Based on morphometric findings, on the 10th day of treatment ,the mean ulcer size of the treatment group with visceral fat was 43.6±0/44 mm2 while the mean size of the ulcer in control group was 98/5±0/07mm2, which has shown to have the least amount of wound contraction. Also on the 5th day, the wound contraction of the treatment group , was twice as high as the control group(p<0.05). The histological examination shows the mean 2.74±0.17 points of restoration parameters score in treatment group compared to the control group with a score of 1.42±0.16 points . Also, the difference between the Hydroxyproline concentration of the healthy skin and the scarring wounds in treatment group (3.69±0.23 mg/g) was less than the control group (6.08±0.32 mg/g) (p<0.05).
According to the evidence of this study, the effect of animal visceral lipid on healing of full tickness skin lesions is because of anti inflammatory role.
wound , visceral fat , rat , fatty acid , hydroxyprolin
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