The Effect of Regular Aerobic Training and Garlic Extract on the Oxidative and Inflammatory Indices of the Heart Tissue of Doxorubicin- induced Elderly Rats
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Introduction

Heart disease is a major cause of mortality in elderly people, and oxidative stress and inflammation lead to changes in myocardium, resulting in apoptosis and cardiac hypertrophy. Accordingly, this study aimed to investigate the effect of 8 weeks of regular aerobic training along with garlic extract consumption on SOD, MDA, CAT, IL-10, and TNF-α levels in the heart tissue of elderly rats with chronic kidney disease.

Materials & Methods

In this experimental study, 42 elderly male Wistar rats (48 to 50 weeks old) were selected and randomly assigned to (1) control, (2) Doxorubicin, (3) Doxorubicin-Saline, (4) Doxorubicin-Training, (5) Doxorubicin-Garlic, and (6) Doxorubicin-Garlic-Training (Combination) groups. Chronic kidney disease was induced with a subcutaneous injection of doxorubicin (8.5 mg/kg). The training program included swimming for eight weeks, three days a week, and thirty minutes per day. Doxorubicin-garlic and combination groups were gavaged with garlic extract (2.5 g /kg body weight). One-way ANOVA was used to analyze the data (p <0.05).

Results

The results showed that eight weeks of swimming training and garlic extract consumption and combination of training and garlic consumption significantly increased SOD, CAT and IL-10 levels, and significantly decreased MDA and TNF-α levels in the heart tissue of elderly rats with chronic kidney disease (p ≤0.05).

Conclusion

Eight weeks of swimming training and garlic extract consumption and combination of training and garlic consumption had significant effect on increasing SOD, CAT and IL-10 levels, and decreasing MDA and TNF-α levels in the heart tissue of elderly rats with chronic kidney disease.

Language:
Persian
Published:
Armaghane-danesh, Volume:24 Issue: 4, 2019
Pages:
597 to 611
magiran.com/p2050001  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!