The effect of combined creatine, glutamine, and turin supplementation on the response to muscle and liver damage induced by high intensity interval exercise in trained men

CGT sport supplement is combined of three creatine, glutamine and taurine supplement that respectively formed 50, 30 and 20 percent of the total content of supplementation. The aim of this study was to investigate the effect of CGT supplementation on response of markers of muscle and liver damage (creatine kinase, lactate dehydrogenase, alanine aminotransferase and aspartate aminotransferase) to high intensity interval exercise in trained men.

Nineteen trained men (age: 22.28±0.73 years; BMI: 22.35±1.66 kg/m2; fat percentage: 8.87±2.93 %) were randomly divided into two groups including CGT supplementation (n=9) and placebo (n=10). Supplementation group consumed CGT supplementation for 2 weeks up to 12 grams per day and placebo group consumed starch powder at same dose. Both groups performed HIIE protocol at pre and post-supplementation that contains the sequences. Blood samples were taken in 6 steps included before, immediately and 2 hours after the pre test, and the same steps in the post-test. The collected data were analyzed using descriptive and inferential statistics and significant level of p

Data analysis showed, creatine kinase and lactate dehydrogenase levels significantly increased immediately and two hours after the exercise in both supplement and placebo groups (p˂0.05). But there was no significant changes in alanine aminotransferase and aspartate aminotransferase levels. (p>0.05). CGT supplementation significantly decreased response of creatine kinase and lactate dehydrogenase to HIIE immediately and 2 hours after the activity (p˂0.05). However, CGT supplementation no significantly affected by changes in alanine aminotransferase and aspartate aminotransferase immediately and 2 hours after HIIE (p>0.05).

Generally, the results indicated that short-term CGT supplementation prevents from muscle damage induced by high intensity interval exercise.