The role of aerobic training in protein expression of stromal cell-derived factor-alpha and apoptotic death of cardiomyocyte after experimental myocardial infarction

Purpose of this study was to investigate the role of aerobic training in protein expression of SDF-1/CXCR4 and cardiomyocyte apoptosis following experimental myocardial infarction in rats.

Twenty six male rats (weight 235 ± 5) were divided into healthy (sham), control, aerobic training and basic group. To induce myocardial infarction subcutaneous injection of isoprenaline (150 mg/kg) on two consecutive days with an interval of 24 hours was used. Aerobic training group started training program 48 hours after induction of myocardial infarction. Training  program include 4 weeks, 5 sessions a week running on a treadmill at a speed of 10-16 meters per minute and a period of 10-50 minutes with a slope of 5 degree. To study the protein expression and apoptosis, immunohistochemistry (IHC) and TUNNEL staining was used respectively. Data were analyzed using one-way ANOVA at p

The results showed that injection of isoprenaline induced apoptosis and increased protein expression of stromal cell-derived factor-alpha and its receptor in infarcted rat hearts. Also, results showed that there was significant difference (p