The effect of eight weeks of continuous and periodic aerobic exercise on serum C-reactive protein and adhesion molecules in men with heart failure

Evidence showed that adhesion molecules and inflammatory factors play an important role in the pathogenesis of atherosclerosis.The purpose of this study was to evaluate the effect of eight weeks of continuous and periodic aerobic exercise on the serum level of C-reactive protein and some adhesive molecules in men with heart failure.

this study, 42 middle-aged men with heart failure were purposeful and randomly divided into three equal groups(14 subjects): continuous aerobic exercise, periodic aerobic exercise and control groups. Continuous training(45-70% of Maximum Heart Rate) and periodic exercise (45-80% of MHR with 5-10 minutes rest between each period) were done for 8 weeks(three days a week). Before and after exercise, blood samples were taken from three groups, ELISA method was used. Data were analyzed using SPSS (20 version) at a significant level of P≤0.05.

After eight weeks of training, the level of C-reactive protein, adhesion molecule -1 and vascular adhesion molecule -1 had a significant decrease in the two training groups(P ≤ 0.05). but no significant difference was observed in the control group. There was a significant difference between the levels of hs-CRP(P = 0.023) and VCAM-1(P = 0.0001) in all three groups, but there was not a significant difference in ICAM-1 level(P = 0.17).ConclusionAerobic exercise by decreasing the levels of hs-CRP and VCAM-1 may play an important role in the prevention and control of cardiovascular disease in men with heart failure.