COMPARISON OF THE EFFECT OF EIGHT WEEKS OF MODERATE CONTINUOUS AND SEVER INTERVAL TRAINING ON CARDIAC ANGIOGENESIS IN WISTAR MALE DIABETIC RATS
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background

Diabetic cardiomyopathy is the first cause of death in diabetic patients and angiogenesis is the most important mechanism for the recovery of heart blood flow in physiologic and pathologic conditions. The purpose of this study was to compare the effect of eight weeks of moderate continuous and sever interval training on heart angiogenesis in Wistar male diabetic rats.

Methods

32 Wistar rats were randomly assigned into 4 groups: healthy non-exercised, diabetic no exercise, diabetic + moderate continuation and diabetic + severe interval exercises. Two types of exercises were calibrated and the exercise intensity was determined based on the maximum oxygen consumption and 5 days a week. The pro-angiogenic (VEGF, MMP2, TGFβ1) and anti-angiogenic (TIMP2) agents of the left ventricle of the heart were taken from the rat after 48 hours of the last training session. Western blot method was used to evaluate the synthesis of proteins involved in angiogenic route. Data were measured by one-way variance analysis with repeated measurements (P =0/000).

Results

The results showed that the levels of proangiogenic VEGF, MMP2, TGFβ1 significantly increased, but the anti-angiogenic factor of TIMP2 decreased (P <0.05). In addition, the maximum level of oxygen consumed in both continuous and periodic training groups showed a significant increase.

Conclusion

Moderate and continuous exercise increases angiogenic factors in the heart of diabetic Wistar rats, which is a good way to reduce the mortality rate of diabetes.

Language:
Persian
Published:
Iranian Journal of Diabetes and Lipid Disorders, Volume:18 Issue: 5, 2019
Pages:
236 to 245
magiran.com/p2053180  
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