Risk factors, and antibiotic resistance pattern of Escherichia coli with extended-spectrum β-lactamase enzyme in west of Iran

Extended-spectrum β-lactamases (ESBL) is present in drug-resistant enterobacteriaceae that is causing many epidemics in hospitals of developing countries; it remarkably limits therapeutic options and increases the rate of motility and morbidity. In order to choose the most appropriate treatment for urinary tract infections (UTI), it is necessary to know its risk factors. The aim of the present study is assessment of risk factors, and antibiotic resistance pattern of Escherichia coli (E. Coli) with ESBL (ESBL-EC) in the patients with UTI in west of Iran.

This case-control study was conducted on patients with UTI referred to Sanandaj Tohid Hospital in Iran during March 2015 to March 2017, who had positive E. coli culture.they were divided into two groups of case (posetive ESBL-EC) and control (negative ESBL-EC) . Demographic data and risk factors findings were compared in the two groups. Using disk diffusion method. Antibiogram test was performed. SPSS software version 21 was used to analyze the data and p ˂0.05 was considered as the significant level.

98 patients with UTI and positive E. coli cultures (49 case and 49 control) were evaluated . Risk of UTI induced ESBL-EC was increased 3.33 times in patients with urinary catheterization in the last 12 months (OR = 3.33; 95% CI: 1.33 – 8.35; p = 0.010).

Based on the findings of this study, urinary catheterization in the last 12 months increased the risk of UTI induced ESBL-EC and cotrimoxazole and ciprofloxacin should not be administered for treating E. coli-induced UTI in Sanandaj.