Highly Sensitive Electrochemical Sensor for the Detection of Paracetamol in Presence of Etilefrine and Dopamine Based on Fe3O4@SiO2 Nanocomposites

In the present study, a highly sensitive electrochemical sensor was developed for the trace analysis of paracetamol using voltammetric techniques. The electrochemical redox behavior of paracetamol was investigated by Fe3O4@SiO2 on surface of GCE using drop casting technique. It showed a supreme electrocatalytic activity at pH 5.5 in 0.1 M PBS. The surface morphology of Fe3O4@SiO2 was studied using SEM and FT-IR. The effect of sweep rate, pH and concentration of paracetamol were investigated. The oxidative peak current of paracetamol was increased linearly while increasing its concentration from 0.8-24 nM and the LOD and LOQ were found to be as low as 4.88 nM (S/N=3) and 19 nM respectively, which is found to be much sensitive than many methods reported in the literature. DPV technique was used for the simultaneous detection of paracetamol in presence of etilefrine and dopamine.