Allelic frequency of rs2070150 polymorphism in patients with type 2 diabetes in a population of Kurdistan province

Type 2 diabetes is a metabolic disorder. Various genetic locations play a role in susceptibility to this disease, including those in the ATF6 (Activating transcription factor. The aim of this study was to investigate the correlation between ATF6 polymorphism (rs2070150) and type 2 diabetes mellitus in patients with type 2 diabetes in Kurdistan.

The present study is a case-control study. A total of 200 blood samples 100 healthy individuals and 100 diabetic patients (age and gender matched)) from the cities of Kurdistan province were screening for ATF6 (rs2070150) polymorphism by Tetra-ARMs PCR method. The obtained data were analyzed using SPSS software and chi-square test.

The results showed that 4, 12 and 84 patients, and 3, 26 and 71 healthy controls, respectively, had CC, CG and GG genotypes.

GC (%42) Genotype in studied population is a risk factor for type 2 diabetes (p=0.041).