Antibacterial Effect of New Compounds Against Lactococcus garvieae

Lactococcus garvieae is one of the most important zoonotic pathogens that threats the aquaculture industry. The recognition and use of new antibacterial compounds is one the best ways to control of this pathogen.In this study, inhibitory effects of Zn nanoparticles, thioethers derivatives, poly-L-lysine, nisin, glycine and hydroalcoholic extracts of Rosemary and Prosopisfarctaleaves were assessed against L. garvieae.

Antibacterial effect of all compounds were evaluated via the disk diffusion and broth microdilution methods. The results were reported as inhibition zone diameter (IZD), the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) values.

Any significant inhibitory effect was observedon L. garvieae with poly-L-lysine, nisin, glycine and hydroalcoholic extracts of Rosemary. Antibacterial effectof twothioethers derivatives, Zn nanoparticles and hydroalcoholic extracts of Prosopis farcta leaves was observed with IZD = 9.48-18.35 mm, MIC = 32-4096 µg/ml and MBC = 64-2048 µg/ml.The best inhibitory effect was belonged tothioethers derivative 4e.

Antibacterial effect of thioethers derivatives, Zn nanoparticles and hydroalcoholic extracts of Prosopis farcta leaves were proven on L. garvieae invitro. New ligands and complexes can be designed according tested thioethers especially derivative 4e in future researches to improve antimicrobial properties.