The study of her2 codon 655 gene polymorphism relationship with ovarian cancer in East Azarbaijan Province

Abstract Ovarian cancer is the most common cancer among women that some environmental and genetic factors contribute to this cancer. Clinical research has shown that excessive expression of HER2 gene leads to carcinogenesis, which includes 20-30% of ovarian and breast cancers. In this study, the polymorphism of a part of codon of 655 HER2(rs1136201) gene associated with ovarian cancer was studied. in this study, the polymorphism of HER2 (1136201) was studied gene in 70 women with ovarian cancer and 70 healthy women in East Azerbaijan province using of BSMI enzyme by PCR-RFLP method. The distribution of polymorphism of HER2 (rs1136201) site provided the most differences in AA genotype between healthy group and unhealthy one (40 against 3); that is, there was a significant difference in the frequency of homozygote genotypes between healthy and patient groups. Chi-Square test used for studying the difference of genotype frequency between two population indicates that there is a significant difference between two population in terms of abundance (p<0/0001), which is the indicator of probable relation of this site with the incidence of disease. The results of this study showed that the polymorphism of HER2 gene increases the risk of ovarian cancer.