The evaluation of the attachment and proliferation of human fibroblast cells on poly(meth) acrylate surfaces.

Growing demand for suitable material for cell culture and biomedical applications has been challenged biomaterial community to looking for compatible materials for cell culture uses. in addition of biocompatibility and having appropriate physical-chemical characteristics, cell culture surfaces should not induce spontaneous differentiation of stem cells and should be suitable with different kind of cells. Among the bulk of existing biomaterials, acrylate and methacrylate combinations of polymers in terms of manufacturing process control, as well as mechanical, physical and chemical properties, are substances that can be used in many cell culture systems.In the present study, a combination of several acrylate monomers was evaluated to determine the attachment and growth of human fibroblast cells. The results confirm the fact that some of these polymer compounds, in terms of cell attachment and growth, are a very suitable substrate for cell culture and expansion, and are in a good agreement with respect to degree of hydrophilicity. Also, the substrates due to having multiple functional groups, in contrast to traditional substrates such as polystyrene, are suitable for covalent binding to other molecules, especially biomolecules, and will be suitable for studying their effects in contact with cells.