Effect of hydro-alcoholic extract of pumpkin seeds on estrogen hormone and liver markers in adult female rats
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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background

Alternative synthetic estrogen replacement hormone therapy has a deleterious effect on the liver tissue. It seems the pumpkin seeds can be a good alternative to hormone therapy. In this regard, this study aimed to investigate the effect of hydro-alcoholic extract of pumpkin seeds on the amount of estrogen hormone in adult female rats and its effects on liver markers And liver and ovarian tissue changes.

Materials and Methods

In this experimental study, 40 immature female wistar rats (in the weight range of 10±180 g and the age of 60 days) were divided into 5 groups of 8 animals: three experimental groups, control and sham groups. The hydro-alcoholic extract of pumpkin seeds was injected intraperitoneally for 21 consecutive days to the experimental groups (doses: 20, 50 and 100 mg/kg body weight). Serum levels of hepatic and ovarian markers were determined and histological studies were performed on the liver and ovary.

Results

Significant decrease in ALP and significant increase in FSH and LH and the graph follicles in experimental group 3 and a significant reduction in the number of primary and primary follicles in the three experimental groups compared to the group Controlling and the number of secondary follicles in the experimental group 1 were observed compared to the experimental groups 2 and 3 (P>0.05).

Conclusion

Estrogen in the hydro-alkali extract of pumpkin seeds without harmful effects on the liver tissue can lead to ovulation and is an appropriate alternative to artificial estrogens and regulating the gastrointestinal tract.

Language:
Persian
Published:
Pages:
455 to 466
magiran.com/p2060929  
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